TUSC2 anticorps (AA 31-100) (Biotin)

N° du produit ABIN713548

Détail du produit anti-TUSC2 anticorps (Biotin)

Antigène: TUSC2 (Tumor Suppressor Candidate 2 (TUSC2))

Épitope: AA 31-100

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TUSC2 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human TUSC2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur TUSC2

Antigène: TUSC2 (Tumor Suppressor Candidate 2 (TUSC2))

Autre désignation: TUSC2 (TUSC2 Produits)

Synonymes: anticorps C3orf11, anticorps FUS1, anticorps PAP, anticorps PDAP2, anticorps TUSC2, anticorps 1190001E22Rik, anticorps AA407686, anticorps Fus1, anticorps Lgcc, anticorps Pdap2, anticorps zgc:92701, anticorps zgc:153746, anticorps tumor suppressor candidate 2, anticorps tumor suppressor candidate 2 L homeolog, anticorps tumor suppressor candidate 2b, anticorps tumor suppressor candidate 2a, anticorps TUSC2, anticorps tusc2.L, anticorps Tusc2, anticorps tusc2b, anticorps tusc2a

Sujet:

Synonyms: C3orf11, FUS1, Fusion 1 protein, PAP, PDAP2, PDGFA associated protein 2, Tumor suppressor candidate 2, TUSC 2, TUSC2_HUMAN.

Background: TUSC2/FUS1 is a novel tumor suppressor gene identified in the human chromosome 3p21.3 region where allele losses and genetic alterations occur early and frequently for many human cancers. Expression of TUSC2 protein is absent or reduced in the majority of lung cancers and premalignant lung lesions. Restoration of TUSC2 function in 3p21.3-deficient non-small cell lung carcinoma cells significantly inhibits tumor cell growth by induction of apoptosis and alteration of cell cycle kinetics. TUSC2 may induce apoptosis through the activation of the intrinsic mitochondrial-dependent and Apaf-1-associated pathways and inhibit the function of protein tyrosine kinases including EGFR, PDGFR, AKT, c-Abl, and c-Kit.

ID gène: 11334