LAT anticorps (Tyr255)

N° du produit ABIN7180039

Détail du produit anti-LAT anticorps

Antigène: LAT (Linker For Activation of T Cells (LAT))

Épitope: Tyr255

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LAT est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain, Souris, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized non-phosphopeptide derived from Human LAT around the phosphorylation site of tyrosine 255.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur LAT

Antigène: LAT (Linker For Activation of T Cells (LAT))

Autre désignation: LAT (LAT Produits)

Synonymes: anticorps LAT, anticorps lat, anticorps LAT1, anticorps pp36, anticorps linker for activation of T-cells, anticorps linker for activation of T cells, anticorps LAT, anticorps lat, anticorps Lat

Sujet:

Background: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Zhang W., Cell 92:83-92(1998).
Martin J., Nature 432:988-994(2004).

Aliases: 36 kDa phospho tyrosine adapter protein antibody, 36 kDa phospho-tyrosine adapter protein antibody, 36 kDa phospho-tyrosine adaptor protein antibody, LAT 1 antibody, lat antibody, LAT_HUMAN antibody, LAT1 antibody, Linker for activation of T cells antibody, Linker for activation of T cells family member 1 antibody, linker for activation of T cells, transmembrane adaptor antibody, Linker for activation of T-cells family member 1 antibody, p36 38 antibody, p36-38 antibody, pp36 antibody

UniProt: O43561

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway