NEUROD1 anticorps (Ser272)

N° du produit ABIN7180052

Détail du produit anti-NEUROD1 anticorps

Antigène: NEUROD1 (Neuronal Differentiation 1 (NEUROD1))

Épitope: Ser272

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEUROD1 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain, Souris

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized non-phosphopeptide derived from Human Neuro D around the phosphorylation site of serine 272 (P-L-S(p)-P-P-).

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur NEUROD1

Antigène: NEUROD1 (Neuronal Differentiation 1 (NEUROD1))

Autre désignation: NEUROD1 (NEUROD1 Produits)

Synonymes: anticorps BETA2, anticorps BHF-1, anticorps MODY6, anticorps NEUROD, anticorps bHLHa3, anticorps Neurod, anticorps neurod, anticorps XNeuroD, anticorps MGC82572, anticorps NEUROD1, anticorps ND1, anticorps beta2, anticorps bhf-1, anticorps neuro-D, anticorps nrd, anticorps neuroD, anticorps neurod1, anticorps Beta2, anticorps neuronal differentiation 1, anticorps neurogenic differentiation 1, anticorps neuronal differentiation 1 S homeolog, anticorps neuronal differentiation 1 L homeolog, anticorps NEUROD1, anticorps Neurod1, anticorps neurod1.S, anticorps neurod1, anticorps neurod1.L

Sujet:

Background: Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis By similarity.

Tamimi R., Genomics 34:418-421(1996).
Yokoyama M., Brain Res. Mol. Brain Res. 42:135-139(1996).
Miyachi T., Brain Res. Mol. Brain Res. 69:223-231(1999)

Aliases: atonal antibody, basic helix loop helix transcription factor antibody, BETA 2 antibody, Beta cell E box transactivator 2 antibody, BETA2 antibody, BHF 1 antibody, BHF1 antibody, bHLHa3 antibody, class A basic helix loop helix protein 3 antibody, Class A basic helix-loop-helix protein 3 antibody, MODY 6 antibody, MODY6 antibody, NDF1_HUMAN antibody, NeuroD antibody, NeuroD1 antibody, Neurogenic differentiation 1 antibody, Neurogenic differentiation factor 1 antibody, neurogenic helix loop helix protein NEUROD antibody, Neuronal differentiation 1 antibody

UniProt: Q13562

Pathways: Dopaminergic Neurogenesis, Hormone Transport, Carbohydrate Homeostasis