PTK2B anticorps (Tyr579)

N° du produit ABIN7180078

Détail du produit anti-PTK2B anticorps

Antigène: PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))

Épitope: Tyr579

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTK2B est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain, Souris

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized non-phosphopeptide derived from Human PYK2 around the phosphorylation site of tyrosine 579 (E-D-Y(p)-Y-K).

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PTK2B

Antigène: PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))

Autre désignation: PTK2B (PTK2B Produits)

Synonymes: anticorps CADTK, anticorps CAKB, anticorps FADK2, anticorps FAK2, anticorps PKB, anticorps PTK, anticorps PYK2, anticorps RAFTK, anticorps CAKbeta, anticorps E430023O05Rik, anticorps Raftk, anticorps Pyk2, anticorps fak1b, anticorps ptk2.2, anticorps ptk2b, anticorps si:ch1073-355e8.1, anticorps protein tyrosine kinase 2 beta, anticorps PTK2 protein tyrosine kinase 2 beta, anticorps protein tyrosine kinase 2aa, anticorps PTK2B, anticorps Ptk2b, anticorps ptk2aa

Sujet:

Background: Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption, this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation, this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca2+ levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC, this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN, this requires both SRC and PTK2/PYK2.

Lev S., Nature 376:737-745(1995).
Herzog H., Genomics 32:484-486(1996).
Sasaki H., J. Biol. Chem. 270:21206-21219(1995).

Aliases: CADTK antibody, CAK-beta antibody, CAKB antibody, CAKbeta antibody, Calcium regulated non receptor proline rich tyrosine kinase antibody, Calcium-dependent tyrosine kinase antibody, Cell adhesion kinase beta antibody, E430023O05Rik antibody, EC 2.7.10.2 antibody, FADK 2 antibody, FADK2 antibody, FAK2 antibody, FAK2_HUMAN antibody, Focal adhesion kinase 2 antibody, MGC124628 antibody, PKB antibody, Proline-rich tyrosine kinase 2 antibody, Protein kinase B antibody, Protein Tyrosine Kinase 2 Beta antibody, Protein-tyrosine kinase 2-beta antibody, PTK antibody, PTK2B antibody, PTK2B protein tyrosine kinase 2 beta antibody, PYK2 antibody, RAFTK antibody, RAFTK2 antibody, Related adhesion focal tyrosine kinase antibody

UniProt: Q14289

Pathways: EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Cell-Cell Junction Organization, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGF Signaling