TK1 anticorps (Ser13)

N° du produit ABIN7180098

Détail du produit anti-TK1 anticorps

Antigène: TK1 (Thymidine Kinase 1, Soluble (TK1))

Épitope: Ser13

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TK1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain, Souris

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized non-phosphopeptide derived from Human TK around the phosphorylation site of serine 13 (P-G-S(p)-P-S).

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TK1

Antigène: TK1 (Thymidine Kinase 1, Soluble (TK1))

Autre désignation: TK1 (TK1 Produits)

Synonymes: anticorps fi19b06, anticorps zgc:55362, anticorps wu:fi19b06, anticorps TK1, anticorps tk2, anticorps D530002A18Rik, anticorps Tk-1, anticorps Tk1a, anticorps Tk1b, anticorps TK2, anticorps Tk, anticorps TK, anticorps thymidine kinase 1, soluble, anticorps thymidine kinase 1, anticorps thymidine kinase, cytosolic, anticorps Thymidine kinase, cytosolic, anticorps temporal expression: early, anticorps thymidine kinase, anticorps Tk thymidine kinase, anticorps tk1, anticorps TK1, anticorps EDI_049980, anticorps kith, anticorps J2R, anticorps HVT031, anticorps Tk1, anticorps tk

Sujet:

Background: Thymidine kinases play a critical role in generating the DNA synthetic precursor deoxythymidine triphosphate (dTTP) by catalyzing the phosphotransfer of phosphate from ATP to deoxythymidine (dT) and thymidine (T) in the cell.TK1 expression and activity is regulated in a cell cycle-dependent manner, accumulating during G1-phase to peak levels in S-phase before being degraded prior to cell division. Stability, but not activity, may be regulated via phosphorylation of TK1 at Ser13 by Cdc2 and/or Cdk2, but the precise mode of regulation remains elusive. These observations indicate that TK1 might be a useful marker of cell proliferation, however, recent studies have shown that TK1 plays a more significant role in the DNA damage response.

N Singh, Mol. Cell. Biol., May 1991, 11: 2362 - 2374.
Bin Tian, Am. J. Pathol., Aug 2003, 163: 789.
RenGerolami, Cancer Res., Feb 2000, 60: 993 - 1001.
Catia Traversari, Blood, Jun 2007, 109: 4708 - 4715

Aliases: cytosolic antibody, KITH_HUMAN antibody, Thymidine kinase 1 antibody, Thymidine kinase 1 soluble antibody, Thymidine kinase 1 soluble isoform antibody, Thymidine kinase antibody, Thymidine kinase cytosolic antibody, TK 1 antibody, TK 2 antibody, TK1 antibody, Tk1a antibody, Tk1b antibody, TK2 antibody

UniProt: P04183