MASTL anticorps (C-Term)

N° du produit ABIN7180197

Détail du produit anti-MASTL anticorps

Antigène: MASTL (Microtubule Associated serine/threonine Kinase-Like (MASTL))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MASTL est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain, Souris

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from C-terminal of Human MASTL.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MASTL

Antigène: MASTL (Microtubule Associated serine/threonine Kinase-Like (MASTL))

Autre désignation: MASTL (MASTL Produits)

Synonymes: anticorps GW, anticorps GWL, anticorps MAST-L, anticorps im:7149025, anticorps wu:fa02a12, anticorps zgc:100990, anticorps MASTL, anticorps GREATWALL, anticorps RP11-85G18.2, anticorps THC2, anticorps hGWL, anticorps 2700091H24Rik, anticorps C88295, anticorps greatwall, anticorps thc2, anticorps microtubule associated serine/threonine kinase-like, anticorps microtubule associated serine/threonine kinase like, anticorps serine/threonine-protein kinase greatwall, anticorps microtubule associated serine/threonine kinase like L homeolog, anticorps mastl, anticorps MASTL, anticorps LOC100541707, anticorps Mastl, anticorps mastl.L

Sujet:

Background: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro, however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.

Ota T., Nat. Genet. 36:40-45(2004).
Deloukas P., Nature 429:375-381(2004).
Beausoleil S.A., Nat. Biotechnol. 24:1285-1292(2006).

Aliases: 2700091H24Rik antibody, C88295 antibody, FLJ14813 antibody, GREATWALL antibody, Greatwall protein kinase antibody, GW antibody, GWL antibody, GWL_HUMAN antibody, hGWL antibody, MAST-L antibody, Mastl antibody, MGC117975 antibody, Microtubule associated serine/threonine kinase like antibody, Microtubule-associated serine/threonine-protein kinase-like antibody, RP11 85G18.2 antibody, Serine/threonine-protein kinase greatwall antibody, THC2 antibody

UniProt: Q96GX5