TRIM24 anticorps (C-Term)

N° du produit ABIN7180275

Détail du produit anti-TRIM24 anticorps

Antigène: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM24 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from C-terminal of Human TRIM24.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TRIM24

Antigène: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Autre désignation: TRIM24 (TRIM24 Produits)

Synonymes: anticorps TRIM24, anticorps PTC6, anticorps RNF82, anticorps TF1A, anticorps TIF1, anticorps TIF1A, anticorps TIF1ALPHA, anticorps hTIF1, anticorps ptc6, anticorps rnf82, anticorps tf1a, anticorps tif1, anticorps tif1a, anticorps tif1alpha, anticorps A130082H20Rik, anticorps AI447469, anticorps D430004I05Rik, anticorps TIF1-alpha, anticorps TIF1alpha, anticorps Tif1a, anticorps tripartite motif containing 24, anticorps transcription intermediary factor 1-alpha, anticorps tripartite motif containing 24 S homeolog, anticorps tripartite motif-containing 24, anticorps TRIM24, anticorps trim24, anticorps LOC100548578, anticorps trim24.S, anticorps Trim24

Sujet:

Background: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes By similarity.

Thenot S., J. Biol. Chem. 272:12062-12068(1997).
Venturini L., Oncogene 18:1209-1217(1999).
Hellal-Levy C., Mol. Endocrinol. 14:1210-1221(2000).

Aliases: E3 ubiquitin protein ligase TRIM24 antibody, E3 ubiquitin-protein ligase Trim24 antibody, hTIF1 antibody, PTC6 antibody, RING finger protein 82 antibody, RNF82 antibody, TF1A antibody, TIF1 alpha antibody, TIF1 antibody, TIF1-alpha antibody, TIF1A antibody, TIF1A_HUMAN antibody, TIF1ALPHA antibody, Transcription intermediary factor 1-alpha antibody, Transcriptional intermediary factor 1 alpha antibody, Transcriptional intermediary factor 1 antibody, Trim24 antibody, Tripartite motif containing 24 antibody, Tripartite motif-containing protein 24 antibody

UniProt: O15164