WTAP anticorps (C-Term)

N° du produit ABIN7180286

Détail du produit anti-WTAP anticorps

Antigène: WTAP (Wilms Tumor 1 Associated Protein (WTAP))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WTAP est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain, Souris

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from C-terminal of Human WTAP.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur WTAP

Antigène: WTAP (Wilms Tumor 1 Associated Protein (WTAP))

Autre désignation: WTAP (WTAP Produits)

Synonymes: anticorps MGC75954, anticorps WTAP, anticorps RGD1563824, anticorps wu:fi29a09, anticorps zgc:66202, anticorps 2810408K05Rik, anticorps 9430038B09Rik, anticorps WT1 associated protein, anticorps Wilms tumor 1 associated protein, anticorps wilms tumor 1 associated protein, anticorps WT1 associated protein L homeolog, anticorps Wilms tumour 1-associating protein, anticorps wtap, anticorps WTAP, anticorps CpipJ_CPIJ006489, anticorps Wtap, anticorps wtap.L

Sujet:

Background: Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing and processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes.

Ortega A., J. Biol. Chem. 278:3040-3047(2003).
Nagase T., DNA Res. 2:37-43(1995).
Mungall A.J., Nature 425:805-811(2003).

Aliases: DKFZp686F20131 antibody, Female-lethal(2)D homolog antibody, FL2D_HUMAN antibody, hFL(2)D antibody, KIAA0105 antibody, MGC3925 antibody, Mum2 antibody, OTTHUMP00000017522 antibody, OTTHUMP00000017523 antibody, PNAS 132 antibody, PNAS-132 antibody, PNAS132 antibody, Pre mRNA splicing regulator WTAP antibody, Pre-mRNA-splicing regulator WTAP antibody, Putative pre mRNA splicing regulator female lethal 2D homolog antibody, Putative pre mRNA splicing regulator female lethal(2D) antibody, Putative pre-mRNA splicing regulator female lethal(2D) homolog antibody, putative pre-mRNA splicing regulator female-lethal(2D) antibody, Wilms tumor 1 associated protein antibody, Wilms tumor 1 associating protein antibody, Wilms tumor 1-associating protein antibody, Wilms' tumor 1 associating protein antibody, Wilms' tumour 1-associating protein antibody, WT1 associated protein antibody, WT1-associated protein antibody, WT1-associating protein antibody, wtap antibody

UniProt: Q15007