Neuregulin 1 anticorps (Isoform 10)

N° du produit ABIN7182178

Détail du produit anti-Neuregulin 1 anticorps

Antigène: Neuregulin 1 (NRG1)

Épitope: Isoform 10

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Neuregulin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Réactivité croisée: Humain, Souris, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from Human NRG1 isoform-10.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Neuregulin 1

Antigène: Neuregulin 1 (NRG1)

Autre désignation: NRG1 (NRG1 Produits)

Synonymes: anticorps 6030402G23Rik, anticorps ARIA, anticorps D230005F13Rik, anticorps GGF, anticorps GGFII, anticorps HRG, anticorps HRGalpha, anticorps Hgl, anticorps NDF, anticorps SMDF, anticorps GGF2, anticorps HGL, anticorps HRG1, anticorps HRGA, anticorps MST131, anticorps NRG-1, anticorps heregulin, anticorps nrg1-A, anticorps pro-neuregulin-1, anticorps NRG1, anticorps wu:fm70e01, anticorps DKFZp459A1838, anticorps neuregulin 1, anticorps histidine rich glycoprotein, anticorps neuregulin 1 L homeolog, anticorps Nrg1, anticorps NRG1, anticorps HRG, anticorps nrg1.L, anticorps nrg1

Sujet:

Background: The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

Xiao-Feng Le, Cancer Res., Jul 2000, 60: 3522 - 3531.
Samuel D. H. Chan, J. Biol. Chem., Sep 1995, 270: 22608.
Daniel C. Gamett, J. Biol. Chem., Aug 1995, 270: 19022.
Mohammed Rahmatullah, Mol. Cell. Biol., Nov 1998, 18: 6245 - 6252.

Aliases: Pro-neuregulin-1, membrane-bound isoform, Pro-NRG1, NRG1, GGF

UniProt: Q15491

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation