CHAF1A anticorps

N° du produit ABIN7183230

Détail du produit anti-CHAF1A anticorps

Antigène: CHAF1A (Chromatin Assembly Factor 1, Subunit A (p150) (CHAF1A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHAF1A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain, Souris

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from internal of Human CAF1A.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000, IHC:1:50-1:200, IF:1:100-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CHAF1A

Antigène: CHAF1A (Chromatin Assembly Factor 1, Subunit A (p150) (CHAF1A))

Autre désignation: CHAF1A (CHAF1A Produits)

Synonymes: anticorps CHAF1A, anticorps CAF-1, anticorps CAF1, anticorps CAF1B, anticorps CAF1P150, anticorps P150, anticorps AL023013, anticorps AL024058, anticorps Cac1p, anticorps CAF-1P150, anticorps CAF-I-p150, anticorps CAF-Ip150, anticorps caip150, anticorps wu:fd14g10, anticorps zgc:153930, anticorps chaf1a-b, anticorps xp150, anticorps chromatin assembly factor 1 subunit A, anticorps chromatin assembly factor 1, subunit A (p150), anticorps chromatin assembly factor 1 subunit A S homeolog, anticorps Chaf1a, anticorps CHAF1A, anticorps LOC100447657, anticorps chaf1a, anticorps chaf1a.S

Sujet:

Background: Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA, histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci By similarity. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

Dong H., Gene 264:187-196(2001) [PubMed: 11250073].
Grimwood J., Nature 428:529-535(2004) [PubMed: 15057824].
Kaufman P.D., Cell 81:1105-1114(1995) [PubMed: 7600578].

Aliases: CAF 1 antibody, CAF 1 subunit A antibody, CAF antibody, CAF I 150 kDa subunit antibody, CAF I p150 antibody, CAF-1 subunit A antibody, CAF-I 150 kDa subunit antibody, CAF-I p150 antibody, CAF1 antibody, CAF1A_HUMAN antibody, CAF1B antibody, CAF1P150 antibody, CHAF1A antibody, Chromatin assembly factor 1 subunit A antibody, Chromatin Assembly Factor 1 Subunit A p150 antibody, Chromatin assembly factor I (150 kDa) antibody, Chromatin assembly factor I 150 kDa antibody, Chromatin assembly factor I p150 subunit antibody, DCAF1 antibody, hp150 antibody, MGC71229 antibody, P150 antibody

UniProt: Q13111