UBR5 anticorps

N° du produit ABIN7183479

Détail du produit anti-UBR5 anticorps

Antigène: UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBR5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Réactivité croisée: Humain, Souris

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from Internal of Human EDD.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur UBR5

Antigène: UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5))

Autre désignation: UBR5 (UBR5 Produits)

Synonymes: anticorps DD5, anticorps EDD, anticorps EDD1, anticorps HYD, anticorps 4432411E13Rik, anticorps AW549941, anticorps C77315, anticorps D030042K14, anticorps Edd, anticorps Edd1, anticorps mKIAA0896, anticorps Dd5, anticorps Rat100, anticorps ubiquitin protein ligase E3 component n-recognin 5, anticorps UBR5, anticorps Ubr5

Sujet:

Background: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation By similarity. Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.

Michelle J. Henderson, J. Biol. Chem., Dec 2006, 281: 39990 - 40000.
Lisa N. Kinch, Protein Sci., Feb 2005, 14: 360 - 367.
Michelle J. Henderson, J. Biol. Chem., Jul 2002, 277: 26468 - 26478.
Darren N. Saunders, Mol. Cell. Biol., Aug 2004, 24: 7225 - 7

Aliases: 4432411E13Rik antibody, AW549941 antibody, C77315 antibody, D030042K14 antibody, DD5 antibody, E3 identified by differential display antibody, E3 ubiquitin protein ligase, HECT domain containing, 1 antibody, E3 ubiquitin-protein ligase antibody, E3 ubiquitin-protein ligase UBR5 antibody, EDD 1 antibody, EDD antibody, EDD1 antibody, FLJ11310 antibody, HECT domain-containing 1 antibody, hHYD antibody, HYD antibody, Hyperplastic discs protein homolog antibody, Hyperplastic discs, Drosophila, homolog of antibody, KIAA0896 antibody, MGC57263 antibody, mKIAA0896 antibody, Progestin induced protein antibody, Progestin-induced protein antibody, Rat100 antibody, Ubiquitin protein ligase antibody, Ubiquitin protein ligase E3 component n recognin 5 antibody, UBR5 antibody, UBR5_HUMAN antibody

UniProt: O95071

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway