POLR3D anticorps

N° du produit ABIN7184078

Détail du produit anti-POLR3D anticorps

Antigène: POLR3D (Polymerase (RNA) III (DNA Directed) Polypeptide D, 44kDa (POLR3D))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POLR3D est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from internal of Human RPC4.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur POLR3D

Antigène: POLR3D (Polymerase (RNA) III (DNA Directed) Polypeptide D, 44kDa (POLR3D))

Autre désignation: POLR3D (POLR3D Produits)

Synonymes: anticorps 2810426M17Rik, anticorps 44kDa, anticorps AI326118, anticorps AW489084, anticorps BN51T, anticorps RPC4, anticorps TSBN51, anticorps RPC53, anticorps RNA polymerase III subunit D, anticorps polymerase (RNA) III (DNA directed) polypeptide D, anticorps Polr3d, anticorps POLR3D

Sujet:

Background: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway By similarity.

Ittmann M., Mol. Cell. Biol. 7:3386-3393(1987).
Hu P., Mol. Cell. Biol. 22:8044-8055(2002).
Kalnine N., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

Aliases: POLR3D antibody, BN51 antibody, BN51T antibody, DNA-directed RNA polymerase III subunit RPC4 antibody, RNA polymerase III subunit C4 antibody, DNA-directed RNA polymerase III subunit D antibody, Protein BN51 antibody, RNA polymerase III 47 kDa subunit antibody, RPC53 homolog antibody

UniProt: P05423