Macrophage Scavenger Receptor 1 anticorps (AA 275-451)

N° du produit ABIN7193254

Détail du produit anti-Macrophage Scavenger Receptor 1 anticorps

Antigène: Macrophage Scavenger Receptor 1 (MSR1)

Épitope: AA 275-451

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Macrophage Scavenger Receptor 1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Fonction: CD204 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human CD204 (AA: 275-451) expressed in E. Coli.

Clone: 5B8H4

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur Macrophage Scavenger Receptor 1

Antigène: Macrophage Scavenger Receptor 1 (MSR1)

Autre désignation: CD204 (MSR1 Produits)

Synonymes: anticorps CD204, anticorps SCARA1, anticorps SR-A, anticorps SRA, anticorps phSR1, anticorps phSR2, anticorps MRS-A, anticorps MSR, anticorps MSR-A, anticorps SR-AI, anticorps SR-AII, anticorps Scara1, anticorps Scvr, anticorps MSR1, anticorps RGD1564316, anticorps macrophage scavenger receptor 1, anticorps scavenger receptor class A member 5, anticorps MSR1, anticorps Msr1, anticorps SCARA5

Sujet:

Description:

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Aliases: MSR1, SRA, SR-A, SR-AI, phSR1, phSR2, SCARA1, SR-AII, SR-AIII

Poids moléculaire: 49.8kDa

ID gène: 4481

UniProt: P21757