TLR3 anticorps (AA 24-217)

N° du produit ABIN7193368

Détail du produit anti-TLR3 anticorps

Antigène: TLR3 (Toll-Like Receptor 3 (TLR3))

Épitope: AA 24-217

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TLR3 est non-conjugé

Application: ELISA, Flow Cytometry (FACS)

Fonction: CD283 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human CD283 (AA: 24-217) expressed in E. Coli.

Clone: 6F3G4

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur TLR3

Antigène: TLR3 (Toll-Like Receptor 3 (TLR3))

Autre désignation: CD283 (TLR3 Produits)

Synonymes: anticorps CD283, anticorps IIAE2, anticorps AI957183, anticorps zgc:123006, anticorps toll like receptor 3, anticorps toll-like receptor 3, anticorps TLR3, anticorps Tlr3, anticorps tlr3

Sujet:

Description:

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]

Aliases: TLR3 , IIAE2

Poids moléculaire: 103.8kDa

ID gène: 7098

UniProt: O15455

Pathways: Signalisation TLR, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades