MTA1 anticorps (AA 541-715)

N° du produit ABIN7193369

Détail du produit anti-MTA1 anticorps

Antigène: MTA1 (Metastasis Associated 1 (MTA1))

Épitope: AA 541-715

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MTA1 est non-conjugé

Application: ELISA, Flow Cytometry (FACS)

Fonction: MTA1 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human MTA1 (AA: 541-715) expressed in E. Coli.

Clone: 7G9C10

Isotype: IgG2a

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur MTA1

Antigène: MTA1 (Metastasis Associated 1 (MTA1))

Autre désignation: MTA1 (MTA1 Produits)

Synonymes: anticorps Tex22, anticorps metastasis associated 1, anticorps metastasis associated 1 L homeolog, anticorps MTA1, anticorps Mta1, anticorps mta1.L

Sujet:

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Poids moléculaire: 80.8kDa

ID gène: 9112

UniProt: Q13330

Pathways: Chromatin Binding