FADD anticorps (AA 20-150)
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- Antigène Voir toutes FADD Anticorps
- FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
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Épitope
- AA 20-150
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp FADD est non-conjugé
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Application
- ELISA, Flow Cytometry (FACS)
- Fonction
- FADD Antibody
- Purification
- Purified antibody
- Immunogène
- Purified recombinant fragment of human FADD (AA: 20-150) expressed in E. Coli.
- Clone
- 5A6A2
- Isotype
- IgG1
- Top Product
- Discover our top product FADD Anticorps primaire
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- Indications d'application
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ELISA: 1/10000
FCM: 1/200 - 1/400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Antigène
- FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
- Autre désignation
- FADD (FADD Produits)
- Sujet
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Description:
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Aliases: GIG3, MORT1
- Poids moléculaire
- 23.3kDa
- ID gène
- 8772
- UniProt
- Q13158
- Pathways
- Apoptose, Signalisation TLR, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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