DFFA anticorps (AA 179-331)

N° du produit ABIN7193432

Détail du produit anti-DFFA anticorps

Antigène: DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))

Épitope: AA 179-331

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DFFA est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Purification: purified

Immunogène: Purified recombinant fragment of human DFFA (AA: 179-331) expressed in E. coli.

Clone: 2B10C8

Isotype: IgG1

Information d'application

Indications d'application: WB:1:500 - 1:2000, FCM:1:200 - 1:400, ELISA:1:10000,

Restrictions: For Research Use only

Stockage

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Détails sur DFFA

Antigène: DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))

Autre désignation: DFFA (DFFA Produits)

Synonymes: anticorps DFF-45, anticorps DFF1, anticorps ICAD, anticorps A330085O09Rik, anticorps DFF35, anticorps Dff45, anticorps ICAD-L, anticorps ICAD-S, anticorps DFFA, anticorps zgc:92229, anticorps DNA fragmentation factor subunit alpha, anticorps DNA fragmentation factor, alpha subunit, anticorps DNA fragmentation factor, 45kDa, alpha polypeptide, anticorps DNA fragmentation factor, alpha polypeptide, anticorps DFFA, anticorps Dffa, anticorps dffa

Sujet:

Description: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Aliases: DFF1, ICAD, DFF-45

Poids moléculaire: 36.5 kDa

ID gène: 1676

Pathways: Apoptose, Caspase Cascade in Apoptosis