MLH1 anticorps (AA 381-483)
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- Antigène Voir toutes MLH1 Anticorps
- MLH1 (MutL Homolog 1 (MLH1))
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Épitope
- AA 381-483
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp MLH1 est non-conjugé
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Application
- ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)
- Fonction
- MLH1 Antibody
- Purification
- Purified antibody
- Immunogène
- Purified recombinant fragment of human MLH1 (AA: 381-483) expressed in E. Coli.
- Clone
- 8C12B7
- Isotype
- IgG2b
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anti-MutL Homolog 1 (MLH1) (AA 381-483) antibody
MLH1 Reactivité: Humain WB, ELISA, IHC, FACS Hôte: Souris Monoclonal 7A7C8 unconjugated
anti-MutL Homolog 1 (MLH1) (AA 1-756) antibodyMLH1 Reactivité: Humain WB, ELISA, IF, IHC (p), PLA Hôte: Souris Monoclonal M1 unconjugated
anti-MutL Homolog 1 (MLH1) (AA 350-519) antibodyMLH1 Reactivité: Humain WB, ELISA, IHC, IF Hôte: Lapin Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) (AA 381-483) antibodyMLH1 Reactivité: Humain, Singe WB, ELISA, IHC, ICC Hôte: Souris Monoclonal 4C9C7 unconjugated
anti-MutL Homolog 1 (MLH1) antibodyMLH1 Reactivité: Humain, Souris WB, IP Hôte: Souris Monoclonal G168-728 unconjugated
anti-MutL Homolog 1 (MLH1) antibodyMLH1 Reactivité: Humain WB, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) (Internal Region) antibodyMLH1 Reactivité: Humain, Souris, Rat WB, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) (Internal Region) antibodyMLH1 Reactivité: Humain, Souris, Rat WB, ELISA, IF Hôte: Lapin Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) (AA 501-600) antibodyMLH1 Reactivité: Humain ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
anti-MutL Homolog 1 (MLH1) (AA 452-480) antibodyMLH1 Reactivité: Humain WB, FACS Hôte: Lapin Polyclonal RB18813 unconjugated
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- Indications d'application
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Antigène
- MLH1 (MutL Homolog 1 (MLH1))
- Autre désignation
- MLH1 (MLH1 Produits)
- Synonymes
- anticorps CG11482, anticorps Dmel\\CG11482, anticorps dmlh-1, anticorps dmlh1, anticorps zgc:66301, anticorps MLH1, anticorps LOC100232198, anticorps 1110035C23Rik, anticorps AI317206, anticorps AI325952, anticorps AI561766, anticorps COCA2, anticorps FCC2, anticorps HNPCC, anticorps HNPCC2, anticorps hMLH1, anticorps mutL homolog 1, anticorps CG11482 gene product from transcript CG11482-RB, anticorps mutL homolog 1 S homeolog, anticorps mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), anticorps DNA mismatch repair protein Mlh1, anticorps MLH1, anticorps Mlh1, anticorps mlh1.S, anticorps mlh1, anticorps LOC588545
- Sujet
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Description:
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).
Aliases: FCC2, COCA2, HNPCC, hMLH1, HNPCC2
- Poids moléculaire
- 84.6kDa
- ID gène
- 4292
- UniProt
- P40692
- Pathways
- Réparation de l'ADN, Production of Molecular Mediator of Immune Response
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