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MLH1 anticorps (AA 381-483)

MLH1 Reactivité: Humain WB, ELISA, IHC, FACS Hôte: Souris Monoclonal 7A7C8 unconjugated
N° du produit ABIN7193587
  • Antigène Voir toutes MLH1 Anticorps
    MLH1 (MutL Homolog 1 (MLH1))
    Épitope
    • 15
    • 10
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 381-483
    Reactivité
    • 79
    • 22
    • 21
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 63
    • 16
    Souris
    Clonalité
    • 57
    • 22
    Monoclonal
    Conjugué
    • 49
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MLH1 est non-conjugé
    Application
    • 43
    • 29
    • 14
    • 13
    • 13
    • 12
    • 11
    • 8
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
    Fonction
    MLH1 Antibody
    Purification
    Purified antibody
    Immunogène
    Purified recombinant fragment of human MLH1 (AA:381-483) expressed in E. Coli.
    Clone
    7A7C8
    Isotype
    IgG1
    Top Product
    Discover our top product MLH1 Anticorps primaire
  • Indications d'application

    ELISA: 1/10000

    FCM: 1/200-1/400

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Antigène
    MLH1 (MutL Homolog 1 (MLH1))
    Autre désignation
    MLH1 (MLH1 Produits)
    Sujet

    Description:

    The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]

    Aliases: FCC2, COCA2, HNPCC, hMLH1, HNPCC2

    Poids moléculaire
    84.6kDa
    ID gène
    4292
    UniProt
    P40692
    Pathways
    Réparation de l'ADN, Production of Molecular Mediator of Immune Response
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