MLH1 anticorps (AA 381-483)
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- Antigène Voir toutes MLH1 Anticorps
- MLH1 (MutL Homolog 1 (MLH1))
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Épitope
- AA 381-483
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp MLH1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
- Fonction
- MLH1 Antibody
- Purification
- Purified antibody
- Immunogène
- Purified recombinant fragment of human MLH1 (AA:381-483) expressed in E. Coli.
- Clone
- 7A7C8
- Isotype
- IgG1
- Top Product
- Discover our top product MLH1 Anticorps primaire
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- Indications d'application
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ELISA: 1/10000
FCM: 1/200-1/400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Antigène
- MLH1 (MutL Homolog 1 (MLH1))
- Autre désignation
- MLH1 (MLH1 Produits)
- Sujet
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Description:
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]
Aliases: FCC2, COCA2, HNPCC, hMLH1, HNPCC2
- Poids moléculaire
- 84.6kDa
- ID gène
- 4292
- UniProt
- P40692
- Pathways
- Réparation de l'ADN, Production of Molecular Mediator of Immune Response
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