HLA-F anticorps (AA 22-305)

N° du produit ABIN7193964

Détail du produit anti-HLA-F anticorps

Antigène: HLA-F (HLAF) (HLA Class I alpha F (HLAF))

Épitope: AA 22-305

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HLA-F est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Purification: purified

Immunogène: Purified recombinant fragment of human HLA-F (AA: 22-305) expressed in E. coli.

Clone: 3F11F4

Isotype: IgG2b

Information d'application

Indications d'application: WB:1:500 - 1:2000, FCM:1:200 - 1:400, ELISA:1:10000,

Restrictions: For Research Use only

Stockage

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Détails sur HLA-F

Antigène: HLA-F (HLAF) (HLA Class I alpha F (HLAF))

Autre désignation: HLA-F (HLAF Produits)

Synonymes: anticorps HLAF, anticorps CDA12, anticorps HLA-5.4, anticorps HLA-CDA12, anticorps major histocompatibility complex, class I, F, anticorps HLA-F

Sujet:

Description: This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.

Aliases: HLAF, CDA12, HLA-5.4, HLA-CDA12

Poids moléculaire: 39 kDa

ID gène: 3134

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Human Leukocyte Antigen (HLA) in Adaptive Immune Response