Caspase 12 anticorps (Internal Region)

N° du produit ABIN7213960

Détail du produit anti-Caspase 12 anticorps

Antigène: Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 12 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Caspase 12 Polyclonal Antibody

Specificité: Caspase12 Polyclonal Antibody detects endogenous levels of Caspase12 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogène: Synthesized peptide derived from the Internal region of human Caspase12

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:40000). Not yet tested in other applications.

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détails sur Caspase 12

Antigène: Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))

Autre désignation: Caspase 12 (CASP12 Produits)

Synonymes: anticorps Caspase-12, anticorps CASP-12, anticorps CASP12P1, anticorps caspase 12, anticorps caspase 12 (gene/pseudogene), anticorps Casp12, anticorps CASP12

Sujet: Rabbit Anti-Caspase12 Polyclonal Antibody,CASP12, Inactive caspase-12, CASP-12,Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. CASP12 is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of CASP12 mediates apoptosis in response to endoplasmic reticulum stress. However, in humans CASP12 contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for CASP12.,Inactive caspase-12

Poids moléculaire: observerd band 50kDa

ID gène: 120329

UniProt: Q6UXS9

Pathways: Apoptose, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response