SH3KBP1 anticorps (AA 591-665) (Biotin)

N° du produit ABIN716218

Détail du produit anti-SH3KBP1 anticorps (Biotin)

Antigène: SH3KBP1 (SH3-Domain Kinase Binding Protein 1 (SH3KBP1))

Épitope: AA 591-665

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SH3KBP1 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Cow,Sheep,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SH3KBP1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur SH3KBP1

Antigène: SH3KBP1 (SH3-Domain Kinase Binding Protein 1 (SH3KBP1))

Autre désignation: SH3KBP1 (SH3KBP1 Produits)

Synonymes: anticorps CD2BP3, anticorps CIN85, anticorps GIG10, anticorps HSB-1, anticorps HSB1, anticorps MIG18, anticorps 1200007H22Rik, anticorps 1700125L08Rik, anticorps 5830464D22Rik, anticorps AI447724, anticorps IN85, anticorps Ruk, anticorps Seta, anticorps SH3 domain containing kinase binding protein 1, anticorps SH3-domain kinase binding protein 1, anticorps SH3 domain-containing kinase-binding protein 1, anticorps SH3KBP1, anticorps sh3kbp1, anticorps LOC100551401, anticorps Sh3kbp1

Sujet:

Synonyms: Cbl interacting protein, Cbl interacting protein of 85 kDa, CD2 binding protein 3, CD2BP3, CIN 85, CIN85, GIG 10, GIG10, HSB 1, Human Src family kinase binding protein 1, MIG 18, MIG18, Migration inducing gene 18 protein, SH3 domain kinase binding protein 1, SH3BP 1, Src family kinase binding protein 1, src related kinase binding protein 1, SH3K1_HUMAN.

Background: SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules, characterized by containing three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The different members of the family orchestrate a network involved in dowregulation and degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. In the case of EGF receptor turnover, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalization. Once internalized, RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation. Alternate splicing results in multiple transcript variants.

ID gène: 30011

Pathways: EGFR Signaling Pathway, EGFR Downregulation