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Smad2/3 anticorps

SMAD2/3 Reactivité: Humain, Rat, Souris, Singe WB, ELISA, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7217046
  • Antigène Tous les produits Smad2/3 (SMAD2/3)
    Smad2/3 (SMAD2/3) (Smad2/3 Transcription Factor (SMAD2/3))
    Reactivité
    • 46
    • 34
    • 33
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    Humain, Rat, Souris, Singe
    Hôte
    • 43
    • 2
    • 1
    • 1
    Lapin
    Clonalité
    • 46
    • 1
    Polyclonal
    Conjugué
    • 22
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Smad2/3 est non-conjugé
    Application
    • 36
    • 14
    • 13
    • 13
    • 10
    • 7
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Fonction
    Smad2/3 Polyclonal Antibody
    Specificité
    Smad2/3 Polyclonal Antibody detects endogenous levels of Smad2/3 protein.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
    Immunogène
    Synthesized peptide derived from human Smad2/3 around the non-phosphorylation site of T8
    Isotype
    IgG
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:10000). Not yet tested in other applications.
    Commentaires

    Primary Antibody

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
  • Antigène
    Smad2/3 (SMAD2/3) (Smad2/3 Transcription Factor (SMAD2/3))
    Autre désignation
    Smad2/3 (SMAD2/3 Produits)
    Sujet
    Rabbit Anti-Smad2/3 Polyclonal Antibody,SMAD2, MADH2, MADR2, Mothers against decapentaplegic homolog 2, MAD homolog 2, Mothers against DPP homolog 2, JV18-1, Mad-related protein 2, hMAD-2, SMAD family member 2, SMAD 2, Smad2, hSMAD2, SMAD3, MADH3, Mothers against decapentaplegic,Mothers against decapentaplegic homolog 2 encoded by SMAD2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF) -beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.,Mothers against decapentaplegic homolog 2
    Poids moléculaire
    observerd band 48kDa
    ID gène
    4087, 4088
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