TMPRSS2 anticorps (AA 301-400) (Biotin)

N° du produit ABIN716878

Détail du produit anti-TMPRSS2 anticorps (Biotin)

Antigène: TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))

Épitope: AA 301-400

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TMPRSS2 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat

Homologie: Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human TMPRSS2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur TMPRSS2

Antigène: TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))

Autre désignation: TMPRSS2 (TMPRSS2 Produits)

Synonymes: anticorps PP9284, anticorps PRSS10, anticorps D16Ertd61e, anticorps transmembrane protease serine 2-like, anticorps transmembrane protease, serine 2, anticorps LOC100739411, anticorps TMPRSS2, anticorps Tmprss2

Sujet:

Synonyms: PP9284, PRSS10, Transmembrane protease serine 2, Serine protease 10, TMPRSS2

Background: Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions, spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9), involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.

ID gène: 7113

UniProt: O15393

Pathways: SARS-CoV-2 Protein Interactome