anticorps ADAM15, anticorps mdc15, anticorps MDC15, anticorps metargidin, anticorps tMDCVI, anticorps ADAM metallopeptidase domain 15, anticorps ADAM metallopeptidase domain 15 L homeolog, anticorps a disintegrin and metallopeptidase domain 15 (metargidin), anticorps ADAM15, anticorps adam15.L, anticorps adam15, anticorps Adam15
Sujet
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],MDC15,Cancer,Cell Adhesion,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,Extracellular Matrix_ADAM Protein Family,Invasion and Metastasis,Signal Transduction,Ubiquitin,ADAM15