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ALK anticorps (AA 19-300)

ALK Reactivité: Humain WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7529465
  • Antigène Voir toutes ALK Anticorps
    ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))
    Épitope
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 19-300
    Reactivité
    • 18
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 18
    • 2
    Lapin
    Clonalité
    • 16
    • 4
    Polyclonal
    Conjugué
    • 17
    • 1
    • 1
    • 1
    Cet anticorp ALK est non-conjugé
    Application
    • 9
    • 8
    • 7
    • 6
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Fonction
    ALK Rabbit pAb
    Séquence
    VGSGMGTGQR AGSPAAGPPL QPREPLSYSR LQRKSLAVDF VVPSLFRVYA RDLLLPPSSS ELKAGRPEAR GSLALDCAPL LRLLGPAPGV SWTAGSPAPA EARTLSRVLK GGSVRKLRRA KQLVLELGEE AILEGCVGPP GEAAVGLLQF NLSELFSWWI RQGEGRLRIR LMPEKKASEV GREGRLSAAI RASQPRLLFQ IFGTGHSSLE SPTNMPSPSP DYFTWNLTWI MKDSFPFLSH RSRYGLECSF DFPCELEYSP PLHDLRNQSW SWRRIPSEEA SQ
     Réactivité croisée
    Humain, Souris
    Attributs du produit
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 19-300 of human ALK (NP_004295.2).
    Isotype
    IgG
    Top Product
    Discover our top product ALK Anticorps primaire
  • Indications d'application
    WB,1:500 - 1:1000,IHC,1:50 - 1:100,IF,1:50 - 1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))
    Autre désignation
    ALK (ALK Produits)
    Synonymes
    anticorps Tcrz, anticorps CD246, anticorps NBLST3, anticorps ALK, anticorps anaplastic lymphoma kinase, anticorps anaplastic lymphoma receptor tyrosine kinase, anticorps ALK receptor tyrosine kinase, anticorps Alk, anticorps ALK
    Sujet
    This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).,ALK,CD246,NBLST3,Cancer,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology & Developmental Biology,Growth factor,Immunology & Inflammation,CD markers,Neuroscience,Cell Type Marker,Neuron marker,ALK
    Poids moléculaire
    176kDa
    ID gène
    238
    UniProt
    Q9UM73
    Pathways
    Signalisation RTK
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