anticorps cb1023, anticorps baiap2l1, anticorps zgc:85624, anticorps RGD1308452, anticorps BAIAP2L1, anticorps MGC131079, anticorps 1300006M19Rik, anticorps AI585895, anticorps IRTKS, anticorps zgc:110192, anticorps BAI1-associated protein 2-like 1a, anticorps BAI1-associated protein 2-like 1, anticorps BAI1 associated protein 2 like 1, anticorps BAI1 associated protein 2 like 1 L homeolog, anticorps BAI1-associated protein 2-like 1b, anticorps baiap2l1a, anticorps Baiap2l1, anticorps BAIAP2L1, anticorps baiap2l1.L, anticorps baiap2l1b
Sujet
This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation.,BAIAP2L1,IRTKS,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,BAIAP2L1