BAZ2A anticorps

N° du produit ABIN7265937

Détail du produit anti-BAZ2A anticorps

Antigène: BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAZ2A est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Fonction: BAZ2A Rabbit pAb

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein of Human BAZ2A.

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur BAZ2A

Antigène: BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))

Autre désignation: BAZ2A (BAZ2A Produits)

Synonymes: anticorps zgc:101601, anticorps tip5, anticorps bax2a, anticorps walp3, anticorps TIP5, anticorps WALp3, anticorps AA415431, anticorps C030005G16Rik, anticorps C78388, anticorps Tip5, anticorps Walp3, anticorps mKIAA0314, anticorps bromodomain adjacent to zinc finger domain, 2A, anticorps bromodomain adjacent to zinc finger domain 2A, anticorps bromodomain adjacent to zinc finger domain 2A L homeolog, anticorps Baz2a, anticorps baz2a, anticorps BAZ2A, anticorps baz2a.L

Sujet: Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template. Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex. The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex. Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac, leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter, pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity.,TIP5,WALp3,BAZ2A / TIP5,BAZ2A,Epigenetics & Nuclear Signaling,BAZ2A

ID gène: 11176

UniProt: Q9UIF9