CDK12 anticorps (AA 80-290)

N° du produit ABIN7266230

Détail du produit anti-CDK12 anticorps

Antigène: CDK12 (CRKRS) (Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS))

Épitope: AA 80-290

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDK12 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Fonction: CDK12 Rabbit pAb

Séquence: SDTFSDDMAF KLDRRENDER RGSDRSDRLH KHRHHQHRRS RDLLKAKQTE KEKSQEVSSK SGSMKDRISG SSKRSNEETD DYGKAQVAKS SSKESRSSKL HKEKTRKERE LKSGHKDRSK SHRKRETPKS YKTVDSPKRR SRSPHRKWSD SSKQDDSPSG ASYGQDYDLS PSRSHTSSNY DSYKKSPGST SRRQSVSPPY KEPSAYQSST R

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 80-290 of human CDK12 (NP_057591.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur CDK12

Antigène: CDK12 (CRKRS) (Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS))

Autre désignation: CDK12 (CRKRS Produits)

Synonymes: anticorps AC017581, anticorps CG7597, anticorps Dmel\\CG7597, anticorps anon-WO0140519.165, anticorps cg7597, anticorps dCDK12, anticorps gi24668141, anticorps CRK7, anticorps CRKR, anticorps CRKRS, anticorps hCDK12, anticorps 1810022J16Rik, anticorps AI646528, anticorps Crk7, anticorps Crkrs, anticorps D11Ertd752e, anticorps Pksc, anticorps Cyclin-dependent kinase 12, anticorps cyclin dependent kinase 12, anticorps cyclin-dependent kinase 12, anticorps Cdk12, anticorps CDK12

Sujet: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD of the large subunit of RNA polymerase II (POLR2A, thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.,CDK12,CRK7,CRKR,CRKRS,Cancer,Signal Transduction,Kinase,Tyrosine kinases,CDK12

Poids moléculaire: 141kDa/163kDa/164kDa

ID gène: 51755

UniProt: Q9NYV4