Chromosome 7 Open Reading Frame 20 (C7orf20) (AA 1-327) anticorps

N° du produit ABIN7266388

Détail du produit

Antigène: Chromosome 7 Open Reading Frame 20 (C7orf20)

Épitope: AA 1-327

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB)

Fonction: GET4 Rabbit pAb

Séquence: MAAAAAMAEQ ESARNGGRNR GGVQRVEGKL RASVEKGDYY EAHQMYRTLF FRYMSQSKHT EARELMYSGA LLFFSHGQQN SAADLSMLVL ESLEKAEVEV ADELLENLAK VFSLMDPNSP ERVTFVSRAL KWSSGGSGKL GHPRLHQLLA LTLWKEQNYC ESRYHFLHSA DGEGCANMLV EYSTSRGFRS EVDMFVAQAV LQFLCLKNKS SASVVFTTYT QKHPSIEDGP PFVEPLLNFI WFLLLAVDGG KLTVFTVLCE QYQPSLRRDP MYNEYLDRIG QLFFGVPPKQ TSSYGGLLGN LLTSLMGSSE QEDGEESPSD GSPIELD

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-327 of human GET4 (NP_057033.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détail du antigène

Antigène: Chromosome 7 Open Reading Frame 20 (C7orf20)

Autre désignation: GET4 (C7orf20 Produits)

Synonymes: anticorps cee, anticorps cgi-20, anticorps c7orf20, anticorps get4, anticorps C7orf20, anticorps CEE, anticorps TRC35, anticorps 1110007L15Rik, anticorps AW412535, anticorps Cee, anticorps RGD1311660, anticorps C25H7ORF20, anticorps get4-a, anticorps golgi to ER traffic protein 4, anticorps chromosome 7 open reading frame 20, anticorps Cee, anticorps golgi to ER traffic protein 4 homolog (S. cerevisiae), anticorps golgi to ER traffic protein 4 S homeolog, anticorps get4, anticorps Bm1_33940, anticorps LOC100136505, anticorps GET4, anticorps Get4, anticorps get4.S

Sujet: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD, a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.,GET4,C7orf20,CEE,CGI-20,TRC35,Cell Biology & Developmental Biology,GET4

Poids moléculaire: 30kDa/36kDa

ID gène: 51608

UniProt: Q7L5D6