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CCDC47 anticorps (AA 224-483)

CCDC47 Reactivité: Humain WB, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7266438
  • Antigène Voir toutes CCDC47 Anticorps
    CCDC47 (Coiled-Coil Domain Containing 47 (CCDC47))
    Épitope
    • 15
    • 3
    • 3
    • 1
    • 1
    • 1
    AA 224-483
    Reactivité
    • 33
    • 21
    • 16
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 36
    Lapin
    Clonalité
    • 36
    Polyclonal
    Conjugué
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp CCDC47 est non-conjugé
    Application
    • 21
    • 13
    • 13
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Fonction
    CCDC47 Rabbit pAb
    Séquence
    FLKRQDLLNV LARMMRPVSD QVQIKVTMND EDMDTYVFAV GTRKALVRLQ KEMQDLSEFC SDKPKSGAKY GLPDSLAILS EMGEVTDGMM DTKMVHFLTH YADKIESVHF SDQFSGPKIM QEEGQPLKLP DTKRTLLFTF NVPGSGNTYP KDMEALLPLM NMVIYSIDKA KKFRLNREGK QKADKNRARV EENFLKLTHV QRQEAAQSRR EEKKRAEKER IMNEEDPEKQ RRLEEAALRR EQKKLEKKQM KMKQIKVKAM
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 224-483 of human CCDC47 (NP_064583.2).
    Isotype
    IgG
  • Indications d'application
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    CCDC47 (Coiled-Coil Domain Containing 47 (CCDC47))
    Autre désignation
    CCDC47 (CCDC47 Produits)
    Synonymes
    anticorps MSTP041, anticorps 2610204L23Rik, anticorps C88307, anticorps RP23-81G14.10, anticorps asp4, anticorps calumin, anticorps RGD1308813, anticorps MGC80951, anticorps zgc:92099, anticorps coiled-coil domain containing 47, anticorps coiled-coil domain containing 47 S homeolog, anticorps CCDC47, anticorps Ccdc47, anticorps ccdc47.S, anticorps ccdc47
    Sujet
    Component of the PAT complex, an endoplasmic reticulum (ER-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs, releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. WDR83OS/Asterix is the substrate-interacting subunit of the PAT complex, whereas CCDC47 is required to maintain the stability of WDR83OS/Asterix. The PAT complex favors the binding to TMDs with exposed hydrophilic amino acids within the lipid bilayer and provides a membrane-embedded partially hydrophilic environment in which the first transmembrane domain binds. Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Involved in the regulation of calcium ion homeostasis in the ER. Required for proper protein degradation via the ERAD (ER-associated degradation pathway. Has an essential role in the maintenance of ER organization during embryogenesis (By similarity.,CCDC47,GK001,MSTP041,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,CCDC47
    Poids moléculaire
    55kDa
    ID gène
    57003
    UniProt
    Q96A33
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