NEDD4-2 anticorps (pSer448)
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- Antigène Voir toutes NEDD4-2 (NEDD4L) Anticorps
- NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))
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Épitope
- pSer448
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp NEDD4-2 est non-conjugé
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Application
- Western Blotting (WB)
- Fonction
- Phospho-NEDD4L-S448 Rabbit pAb
- Séquence
- SLSSP
- Réactivité croisée
- Humain, Souris, Rat
- Attributs du produit
- Phosphorylated Antibodies
- Purification
- Affinity purification
- Immunogène
- A synthetic phosphorylated peptide around S448 of human NEDD4L (NP_001138439.1).
- Isotype
- IgG
- Top Product
- Discover our top product NEDD4L Anticorps primaire
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- Indications d'application
- WB,1:500 - 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))
- Autre désignation
- NEDD4L (NEDD4L Produits)
- Sujet
- This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.,NEDD4L,NEDD4-2,NEDD4.2,PVNH7,RSP5,hNEDD4-2,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,Protein phosphorylation,NEDD4L
- Poids moléculaire
- 96-111kDa
- ID gène
- 23327
- UniProt
- Q96PU5
- Pathways
- Negative Regulation of Transporter Activity
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