FGL1 anticorps

N° du produit ABIN7267179

Détail du produit anti-FGL1 anticorps

Antigène: FGL1 (Fibrinogen-Like 1 (FGL1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp FGL1 est non-conjugé

Application: Western Blotting (WB)

Fonction: FGL1 Rabbit mAb

Réactivité croisée: Humain

Attributs du produit: Monoclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant protein of human FGL-1 Full length.

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.09 % sodium azide,50 % glycerol, pH 7.4.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur FGL1

Antigène: FGL1 (Fibrinogen-Like 1 (FGL1))

Autre désignation: FGL1 (FGL1 Produits)

Sujet: Fibrinogen-like protein 1 (FGL1), a liver-secreted protein, is a major LAG-3 functional ligand independent from MHC-II. The FGL1-LAG-3 pathway maybe an important immune evasion mechanism and could contribute to current cancer immunotherapy efforts for several reasons. FGL1 inhibits antigen-specific T cell activation, and ablation of FGL1 in mice promotes T cell immunity. Blockade of the FGL1-LAG-3 interaction by monoclonal antibodies stimulates tumor immunity and is therapeutic against established mouse tumors in a receptor-ligand inter-dependent manner. FGL1 is highly produced by human cancer cells, and elevated FGL1 in the plasma of cancer patients is associated with a poor prognosis and resistance to anti-PD-1/B7-H1 therapy,FGL1,HFREP1,HP-041,LFIRE-1,LFIRE1,Cardiovascular,Blood,Coagulation,Serum Proteins,FGL1

Poids moléculaire: 36kDa

ID gène: 2267

UniProt: Q08830