GAPVD1 anticorps (AA 1-260)

N° du produit ABIN7267529

Détail du produit anti-GAPVD1 anticorps

Antigène: GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))

Épitope: AA 1-260

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GAPVD1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Fonction: GAPVD1 Rabbit pAb

Séquence: MVKLDIHTLA HHLKQERLYV NSEKQLIQRL NADVLKTAEK LYRTAWIAKQ QRINLDRLII TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL SRLRENPRLI ASSLVAGEKL NQENTQSVIY TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI LFKLFSEGLF SAKLFLTATL HEPIMQLLVE DEDHLETDPN KLIERFSPSQ QEKLFGEKGS DRFRQKVQEM VESNEAKLVA

Réactivité croisée: Souris

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human GAPVD1 (NP_056450.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur GAPVD1

Antigène: GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))

Autre désignation: GAPVD1 (GAPVD1 Produits)

Synonymes: anticorps zgc:92666, anticorps GAPEX5, anticorps RAP6, anticorps 2010005B09Rik, anticorps 4432404J10Rik, anticorps AW108497, anticorps Gapex-5, anticorps RME-6, anticorps mKIAA1521, anticorps RGD1307479, anticorps GTPase activating protein and VPS9 domains 1, anticorps GTPase activating protein and VPS9 domains 1 S homeolog, anticorps LOAG_00609, anticorps GAPVD1, anticorps gapvd1, anticorps gapvd1.S, anticorps Gapvd1

Sujet: Acts both as a GTPase-activating protein (GAP and a guanine nucleotide exchange factor (GEF, and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras.,GAPVD1,GAPEX5,GAPex-5,RAP6,Cancer,Signal Transduction,G protein signaling,Signal Transduction,Endocrine & Metabolism,GAPVD1

Poids moléculaire: 165kDa

ID gène: 26130

UniProt: Q14C86