HBEGF anticorps (AA 20-160)

N° du produit ABIN7267617

Détail du produit anti-HBEGF anticorps

Antigène: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Épitope: AA 20-160

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HBEGF est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Fonction: HB-EGF Rabbit pAb

Séquence: LVTGESLERL RRGLAAGTSN PDPPTVSTDQ LLPLGGGRDR KVRDLQEADL DLLRVTLSSK PQALATPNKE EHGKRKKKGK GLGKKRDPCL RKYKDFCIHG ECKYVKELRA PSCICHPGYH GERCHGLSLP VENRLYTYDH T

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 20-160 of human HB-EGF (NP_001936.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur HBEGF

Antigène: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Autre désignation: HBEGF (HBEGF Produits)

Synonymes: anticorps hbegf, anticorps zgc:165443, anticorps HBEGF, anticorps zgc:175091, anticorps DTR, anticorps DTS, anticorps DTSF, anticorps HEGFL, anticorps Dtr, anticorps GFHB, anticorps Hb-egf, anticorps Hegfl, anticorps AW047313, anticorps Dts, anticorps HB-EGF, anticorps heparin-binding EGF-like growth factor b, anticorps heparin binding EGF like growth factor, anticorps Heparin-binding EGF-like growth factor, anticorps heparin-binding EGF-like growth factor a, anticorps heparin-binding EGF-like growth factor, anticorps hbegfb, anticorps HBEGF, anticorps hbegf, anticorps hbegfa, anticorps Hbegf

Sujet: Heparin-binding EGF-like growth factor (HB-EGF) is a 12-16 kDa member of the epidermal growth factor (EGF)family. It possesses an EGF-like domain, and a heparin-binding motif. Mature HB-EGF is a soluble peptide thatarises from proteolytic processing of the transmembrane form. Human HB -EGF shows 76 % and 73 % aasequence identity with rat and mouse HB-EGF, respectively. It is required for normal cardiac valve formationand normal heart function, promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation, it is mitogenic for fibroblasts, but not endothelial cells. HB-EGF classified as agroup 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activityassociated with ErbB4 binding appears to be limited to non -mitogenic actions, while EGFR binding inducesboth mitogenic and non-mitogenic activity.,HBEGF,DTR,DTS,DTSF,HEGFL,Cancer,Invasion and Metastasis,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Growth factor,EGF,Cardiovascular,Angiogenesis,Angiogenic growth factors,HBEGF

Poids moléculaire: 23kDa

ID gène: 1839

UniProt: Q99075

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway