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TIM3 anticorps

TIM 3 Reactivité: Souris WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7267618
  • Antigène Voir toutes TIM3 (TIM 3) Anticorps
    TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
    Reactivité
    • 76
    • 42
    • 4
    • 3
    • 2
    • 1
    • 1
    Souris
    Hôte
    • 48
    • 33
    • 29
    • 2
    • 1
    Lapin
    Clonalité
    • 67
    • 45
    • 1
    Polyclonal
    Conjugué
    • 63
    • 10
    • 10
    • 9
    • 8
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TIM3 est non-conjugé
    Application
    • 50
    • 43
    • 36
    • 22
    • 16
    • 7
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Fonction
    HAVCR2 Rabbit pAb
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogène
    Recombinant protein of Mouse HAVCR2.
    Isotype
    IgG
    Top Product
    Discover our top product TIM 3 Anticorps primaire
  • Indications d'application
    WB,1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
    Autre désignation
    HAVCR2 (TIM 3 Produits)
    Synonymes
    anticorps HAVCR2, anticorps MGC140131, anticorps HAVcr-2, anticorps KIM-3, anticorps TIM3, anticorps TIMD-3, anticorps TIMD3, anticorps Tim-3, anticorps TIM-3, anticorps Tim3, anticorps Timd3, anticorps tim3, anticorps hepatitis A virus cellular receptor 2, anticorps HAVCR2, anticorps Havcr2
    Classe de substances
    Virus
    Sujet
    T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), isa transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important rolein the Th1-mediated immune response. TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, anddendritic cells, but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosisof apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interactionwith phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressivefunctions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with anagonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is alsoregarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as twoimportant coinhibitory regulators of T cell responses, have been implicated with the T-cell dysfunction orexhaustion associated with chronic HBV infection including HBV-related HCC.,Tim, TIM-, Tim3, Timd, TIM-3, Timd3,HAVCR2
    Poids moléculaire
    30kDa
    ID gène
    171285
    UniProt
    Q8VIM0
    Pathways
    Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints
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