This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016],IKBKG, AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IKKAP1, IKKG, IMD33, IP, IP1, IP2, IPD2, NEMO, ZC2HC9, NF-kappa-B essential modulator,Apoptosis,Apoptosis_Inhibition of Apoptosis,B Cell Receptor Signaling Pathway,Cardiovascular,Cell Biology & Developmental Biology,Cell Intrinsic Innate Immunity Signaling Pathway,Death Receptor Signaling Pathway,Endocrine & Metabolism,Epigenetics & Nuclear Signaling,Immunology & Inflammation,Innate Immunity_TLR Signaling,Insulin Receptor Signaling Pathway,Kinase,Kinase_Serine/threonine kinases,NF-kB Signaling Pathway,Signal Transduction,T Cell Receptor Signaling Pathway,Toll-like Receptor Signaling Pathway,IKBKG