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INSIG1 anticorps (C-Term)

INSIG1 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7267887
  • Antigène Voir toutes INSIG1 Anticorps
    INSIG1 (Insulin Induced Gene 1 (INSIG1))
    Épitope
    • 7
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 28
    • 9
    • 7
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 28
    Lapin
    Clonalité
    • 28
    Polyclonal
    Conjugué
    • 16
    • 4
    • 2
    • 2
    • 2
    • 2
    Cet anticorp INSIG1 est non-conjugé
    Application
    • 24
    • 17
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Fonction
    INSIG1 Rabbit pAb
    Séquence
    LWWTFDRSRS GLGLGITIAF LATLITQFLV YNGVYQYTSP DFLYIRSWLP CIFFSGGVTV GNIGRQLAMG VPEKPHSD
     Réactivité croisée
    Humain, Rat
    Attributs du produit
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogène
    A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human INSIG1 (NP_005533.2).
    Isotype
    IgG
    Top Product
    Discover our top product INSIG1 Anticorps primaire
  • Indications d'application
    WB,1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    INSIG1 (Insulin Induced Gene 1 (INSIG1))
    Autre désignation
    INSIG1 (INSIG1 Produits)
    Synonymes
    anticorps cl-6, anticorps cl6, anticorps CL-6, anticorps CL6, anticorps fb55a03, anticorps fi35b10, anticorps wu:fb55a03, anticorps wu:fi35b10, anticorps zgc:55439, anticorps 1810013C12Rik, anticorps Insig-1, anticorps INSIG-1, anticorps insulin induced gene 1, anticorps insulin induced gene 1 L homeolog, anticorps INSIG1, anticorps insig1, anticorps insig1.L, anticorps Insig1
    Sujet
    This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants.,INSIG1,CL6,Cancer,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Cardiovascular,Lipids,INSIG1
    Poids moléculaire
    17kDa/29kDa
    ID gène
    3638
    UniProt
    O15503
    Pathways
    ER-Nucleus Signaling
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