KLHDC2 anticorps (AA 1-240)

N° du produit ABIN7268073

Détail du produit anti-KLHDC2 anticorps

Antigène: KLHDC2 (Kelch Domain Containing 2 (KLHDC2))

Épitope: AA 1-240

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KLHDC2 est non-conjugé

Application: Western Blotting (WB)

Fonction: KLHDC2 Rabbit pAb

Séquence: MADGNEDLRA DDLPGPAFES YESMELACPA ERSGHVAVSD GRHMFVWGGY KSNQVRGLYD FYLPREELWI YNMETGRWKK INTEGDVPPS MSGSCAVCVD RVLYLFGGHH SRGNTNKFYM LDSRSTDRVL QWERIDCQGI PPSSKDKLGV WVYKNKLIFF GGYGYLPEDK VLGTFEFDET SFWNSSHPRG WNDHVHILDT ETFTWSQPIT TGKAPSPRAA HACATVGNRG FVFGGRYRDA

Réactivité croisée: Humain

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human KLHDC2 (NP_055130.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur KLHDC2

Antigène: KLHDC2 (Kelch Domain Containing 2 (KLHDC2))

Autre désignation: KLHDC2 (KLHDC2 Produits)

Synonymes: anticorps MGC82652, anticorps HCLP-1, anticorps HCLP1, anticorps LCP, anticorps 2310022K15Rik, anticorps D12Ertd522e, anticorps kelch domain containing 2 L homeolog, anticorps kelch domain containing 2, anticorps klhdc2.L, anticorps KLHDC2, anticorps Klhdc2

Sujet: Substrate-recognition component of a Cul2-RING (CRL2 E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC2 complex specifically recognizes proteins with a diglycine (Gly-Gly at the C-terminus, leading to their ubiquitination and degradation. The CRL2(KLHDC2 complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine. The CRL2(KLHDC2 complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation. May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding.,KLHDC2,HCLP-1,HCLP1,LCP,Epigenetics & Nuclear Signaling,KLHDC2

Poids moléculaire: 28kDa/46kDa

ID gène: 23588

UniProt: Q9Y2U9