This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013],RBBP-2, RBBP2, RBP2,Cell Biology & Developmental Biology,Epigenetic writers and erasers of core Histones,Epigenetic writers and erasers of core Histones_Demethylation,Epigenetics & Nuclear Signaling,Notch Signaling Pathway,Nuclear Receptor Signaling,Transcription Factors,KDM5A