HLA-DMB anticorps

N° du produit ABIN7268368

Détail du produit anti-HLA-DMB anticorps

Antigène: HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp HLA-DMB est non-conjugé

Application: Western Blotting (WB)

Fonction: HLA-DMB Rabbit mAb

Réactivité croisée: Humain

Attributs du produit: Monoclonal Antibodies

Purification: Affinity purification

Immunogène: A synthesized peptide derived from human HLA-DMB.

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur HLA-DMB

Antigène: HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))

Autre désignation: HLA DMB (HLA-DMB Produits)

Synonymes: anticorps RING7, anticorps D6S221E, anticorps RT1.DMb, anticorps RT1.Mb, anticorps MHC-DMB, anticorps major histocompatibility complex, class II, DM beta, anticorps RT1 class II, locus DMb, anticorps HLA-DMB, anticorps RT1-DMb, anticorps PATR-DMB

Sujet: HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.,HLA-DMB, D6S221E, RING7, major histocompatibility complex, class II, DM beta,Immunology & Inflammation,HLA DMB

Poids moléculaire: 29kDa

ID gène: 3109

UniProt: P28068

Pathways: Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response