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MPL anticorps

MPL Reactivité: Humain WB Hôte: Lapin Monoclonal unconjugated
N° du produit ABIN7268727
  • Antigène Voir toutes MPL Anticorps
    MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
    Reactivité
    • 56
    • 26
    • 22
    • 1
    • 1
    Humain
    Hôte
    • 51
    • 8
    Lapin
    Clonalité
    • 53
    • 6
    Monoclonal
    Conjugué
    • 20
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Cet anticorp MPL est non-conjugé
    Application
    • 39
    • 35
    • 15
    • 13
    • 13
    • 9
    • 6
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Fonction
    TPO-R/CD110/c-Mpl Rabbit mAb
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Monoclonal Antibodies
    Purification
    Affinity purification
    Immunogène
    A synthesized peptide derived from human TPO-R/CD110/c-Mpl
    Isotype
    IgG
    Top Product
    Discover our top product MPL Anticorps primaire
  • Indications d'application
    WB,1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
    Autre désignation
    MPL (MPL Produits)
    Synonymes
    anticorps C-MPL, anticorps CD110, anticorps MPLV, anticorps THCYT2, anticorps TPOR, anticorps TPO-R, anticorps c-mpl, anticorps c-mpl-I, anticorps c-mpl-II, anticorps hlb219, anticorps MPL, anticorps mpll, anticorps tpor, anticorps tpor.b, anticorps MPL proto-oncogene, thrombopoietin receptor, anticorps myeloproliferative leukemia virus oncogene, anticorps MPL, anticorps Mpl, anticorps mpl
    Sujet
    In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008],C-MPL, CD110, MPLV, THCYT2, TPOR,CDs,Hematopoietic Progenitors,Immunology & Inflammation,Stem Cells,MPL
    Poids moléculaire
    82kDa
    ID gène
    4352
    UniProt
    P40238
    Pathways
    Signalistation JAK/STAT
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