AF9 anticorps (AA 1-150)

N° du produit ABIN7269603

Détail du produit anti-AF9 anticorps

Antigène: AF9 (MLLT3) (Protein AF-9 (MLLT3))

Épitope: AA 1-150

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AF9 est non-conjugé

Application: Western Blotting (WB)

Fonction: MLLT3/AF9 Rabbit pAb

Séquence: MASSCAVQVK LELGHRAQVR KKPTVEGFTH DWMVFVRGPE HSNIQHFVEK VVFHLHESFP RPKRVCKDPP YKVEESGYAG FILPIEVYFK NKEEPRKVRF DYDLFLHLEG HPPVNHLRCE KLTFNNPTED FRRKLLKAGG DPNRSIHTSS

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human MLLT3/AF9 (NP_004520.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur AF9

Antigène: AF9 (MLLT3) (Protein AF-9 (MLLT3))

Autre désignation: MLLT3 (MLLT3 Produits)

Synonymes: anticorps fc39c11, anticorps wu:fc39c11, anticorps zgc:110210, anticorps AF9, anticorps YEATS3, anticorps 2210011H10Rik, anticorps 2610012I03Rik, anticorps 3830408D16Rik, anticorps Af9, anticorps D4Ertd321e, anticorps Af-9, anticorps MLLT3, super elongation complex subunit, anticorps myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3, anticorps mllt3, anticorps MLLT3, anticorps Mllt3

Sujet: Chromatin reader component of the super elongation complex (SEC, a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr, and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr. Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively, but with lower affinity than crotonylated histone H3. In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones. Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me. Plays a key role in hematopoietic stem cell (HSC maintenance by preserving, rather than confering, HSC stemness. Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L.,MLLT3,AF9,YEATS3,Epigenetics & Nuclear Signaling,Cancer,MLLT3

Poids moléculaire: 63kDa

ID gène: 4300

UniProt: P42568