SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8) anticorps

N° du produit ABIN7270150

Détail du produit

Antigène: SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8)

Reactivité: SARS Coronavirus-2 (SARS-CoV-2)

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Immunofluorescence (IF), Western Blotting (WB)

Fonction: SARS-CoV-2 3CLpro Rabbit mAb

Réactivité croisée: SARS Coronavirus-2 (SARS-CoV-2)

Attributs du produit: Monoclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein of SARS-CoV-2 3CLpro.

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détail du antigène

Antigène: SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8)

Autre désignation: 3CLpro (SARS-CoV NSP8 Produits)

Synonymes: anticorps pp1a, anticorps pp1ab, anticorps orf1ab polyprotein (pp1ab), anticorps orf1ab

Classe de substances: Viral Protein

Sujet: [Spike protein S1]: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein. Binding to host NRP1 and NRP2 via C-terminal polybasic sequence enhances virion entry into host cell. This interaction may explain virus tropism of human olfactory epithelium cells, which express high level of NRP1 and NRP2 but low level of ACE2. The stalk domain of S contains three hinges, giving the head unexpected orientational freedom. Uses human TMPRSS2 for priming in human lung cells which is an essential step for viral entry. Can be alternatively processed by host furin. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.,3CLpro

ID gène: 43740578

UniProt: P0DTC2