anticorps Gm1349, anticorps 2310020L09Rik, anticorps sec24d, anticorps SEC24 homolog D, COPII coat complex component, anticorps Sec24 related gene family, member D (S. cerevisiae), anticorps SEC24 homolog D, COPII coat complex component S homeolog, anticorps SEC24D, anticorps Sec24d, anticorps sec24d.S
Sujet
The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. This gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration. Mutations in this gene have been associated with Cole-Carpenter syndrome, a disorder affecting bone formation, resulting in craniofacial malformations and bones that break easily. Alternative splicing results in multiple transcript variants encoding different isoforms.,SEC24D,CLCRP2,Signal Transduction,SEC24D