SEPN1 anticorps (AA 341-590)

N° du produit ABIN7270196

Détail du produit anti-SEPN1 anticorps

Antigène: SEPN1 (Selenoprotein N, 1 (SEPN1))

Épitope: AA 341-590

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SEPN1 est non-conjugé

Application: Western Blotting (WB)

Fonction: SEPN1 Rabbit pAb

Séquence: VDMEWLYGAS ESSNMEVDIG YIPQMELEAT GPSVPSVILD EDGSMIDSHL PSGEPLQFVF EEIKWQQELS WEEAARRLEV AMYPFKKVSY LPFTEAFDRA KAENKLVHSI LLWGALDDQS CUGSGRTLRE TVLESSPILT LLNESFISTW SLVKELEELQ NNQENSSHQK LAGLHLEKYS FPVEMMICLP NGTVVHHINA NYFLDITSVK PEEIESNLFS FSSTFEDPST ATYMQFLKEG LRRGLPLLQP

Réactivité croisée: Humain, Souris

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 341-590 of human SEPN1 (NP_065184.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur SEPN1

Antigène: SEPN1 (Selenoprotein N, 1 (SEPN1))

Autre désignation: SEPN1 (SEPN1 Produits)

Synonymes: anticorps CFTD, anticorps MDRS1, anticorps RSMD1, anticorps RSS, anticorps SELN, anticorps 1110019I12Rik, anticorps AI414492, anticorps SePN, anticorps cb686, anticorps wu:fb06g01, anticorps wu:fb73d02, anticorps wu:fv41b08, anticorps zgc:101091, anticorps selenoprotein N, anticorps SELENON, anticorps Selenon, anticorps selenon

Sujet: This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in this gene are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. SEPN1-related myopathy consists of 4 autosomal recessive disorders, originally thought to be separate entities: rigid spine muscular dystrophy (RSMD1), the classical form of multiminicore disease, desmin related myopathy with Mallory-body like inclusions, and congenital fiber-type disproportion (CFTD). This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. Alternatively spliced transcript variants have been found for this gene.,SELENON,CFTD,MDRS1,RSMD1,RSS,SELN,SEPN1,SEPN1

Poids moléculaire: 62kDa/65kDa

ID gène: 57190

UniProt: Q9NZV5

Pathways: Skeletal Muscle Fiber Development