SMAD4 anticorps

N° du produit ABIN7270340

Détail du produit anti-SMAD4 anticorps

Antigène: SMAD4 (SMAD Family Member 4 (SMAD4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp SMAD4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Fonction: [KO Validated] Smad4 Rabbit mAb

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Monoclonal Antibodies

Purification: Affinity purification

Classe de qualité: KO Validated

Immunogène: Recombinant protein of human Smad4.

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IP,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur SMAD4

Antigène: SMAD4 (SMAD Family Member 4 (SMAD4))

Autre désignation: SMAD4 (SMAD4 Produits)

Synonymes: anticorps smad4, anticorps DPC4, anticorps JIP, anticorps MADH4, anticorps MYHRS, anticorps AW743858, anticorps D18Wsu70e, anticorps Madh4, anticorps XSmad4alpha, anticorps Xsmad4, anticorps dpc4, anticorps jip, anticorps madh4, anticorps xsmad4a, anticorps SMAD family member 4, anticorps Smad4 protein, anticorps SMAD family member 4, gene 1 L homeolog, anticorps SMAD4, anticorps smad4, anticorps Smad4, anticorps smad4.1.L

Sujet: This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Oct 2009],DPC4,JIP,MADH4,MYHRS,Smad4,SMAD4,Apoptosis,Cancer,Cardiovascular,Cell Biology & Developmental Biology,Cell Cycle,Endocrine & Metabolism,Epigenetics & Nuclear Signaling,ESC Pluripotency and Differentiation,G1/S Checkpoint,Heart,Heart_Cardiogenesis,Heart_Hypertrophy,Hypoxia,MAPK-JNK Signaling Pathway,Signal Transduction,Stem Cells,TGF-b-Smad Signaling Pathway,TGF-b-Smad Signaling Pathway_SMADs,Transcription Factors,Tumor suppressors,SMAD4

Poids moléculaire: 65kDa

ID gène: 4089

UniProt: Q13485

Pathways: Cycle Cellulaire, Chromatin Binding, Autophagy