SPRY3 anticorps (C-Term)
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- Antigène Voir toutes SPRY3 Anticorps
- SPRY3 (Sprouty Homolog 3 (SPRY3))
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Épitope
- C-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SPRY3 est non-conjugé
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Application
- Western Blotting (WB)
- Fonction
- SPRY3 Rabbit pAb
- Séquence
- TDDEDNCADE PCSCGPSSCF VRWAAMSLIS LFLPCLCCYL PTRGCLHLCQ QGYDSLRRPG CRCKRHTNTV CRKISSGSAP FPKAQEKSV
- Réactivité croisée
- Humain
- Attributs du produit
- Polyclonal Antibodies
- Purification
- Affinity purification
- Immunogène
- A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human SPRY3 (NP_005831.1).
- Isotype
- IgG
- Top Product
- Discover our top product SPRY3 Anticorps primaire
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- Indications d'application
- WB,1:500 - 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- SPRY3 (Sprouty Homolog 3 (SPRY3))
- Autre désignation
- SPRY3 (SPRY3 Produits)
- Sujet
- Members of the Sprouty family (Sprouty 1-4) are inducible negative regulators of growth factors that act through tyrosine kinase receptors. Mammalian Sprouty homologs share a well-conserved cysteine-rich carboxy-terminal domain with their Drosophila counterparts. Sprouty proteins are cytoplasmic in unstimulated cells, but in cells stimulated by growth factors they anchor to the plasma membrane by palmitoylation. Sprouty 1 and 2 associate with caveolin-1 in perinuclear and vesicular structures and are phosphorylated on serine residues. Sprouty 2 can associate with c-Cbl, a downregulator of RTK signaling, and inhibit the activities of several growth factors. Unlike the widely expressed Sprouty members 1, 2 and 4, Sprouty 3 expression is restricted to adult brain and testis. Sprouty 4 is a target of the WNT/b-catenin signaling pathway in progenitor cells. In conclusion, members of Sprouty inhibit FGF and VEGF-mediated cell proliferation, suggesting that they may regulate angiogenesis in normal and disease processes.,SPRY3,spry-3,Signal Transduction,ErbB-HER Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Growth factor,SPRY3
- Poids moléculaire
- 31kDa
- ID gène
- 10251
- UniProt
- O43610
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