SENP6 anticorps (AA 811-1112)

N° du produit ABIN7270635

Détail du produit anti-SENP6 anticorps

Antigène: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Épitope: AA 811-1112

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SENP6 est non-conjugé

Application: Western Blotting (WB)

Fonction: SENP6 Rabbit pAb

Séquence: MESCSQNSSA KPVIKKMLNK KHCIAVIDSN PGQEESDPRY KRNICSVKYS VKKINHTASE NEEFNKGEST SQKVADRTKS ENGLQNESLS STHHTDGLSK IRLNYSDESP EAGKMLEDEL VDFSEDQDNQ DDSSDDGFLA DDNCSSEIGQ WHLKPTICKQ PCILLMDSLR GPSRSNVVKI LREYLEVEWE VKKGSKRSFS KDVMKGSNPK VPQQNNFSDC GVYVLQYVES FFENPILSFE LPMNLANWFP PPRMRTKREE IRNIILKLQE DQSKEKRKHK DTYSTEAPLG EGTEQYVNSI SD

Réactivité croisée: Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 811-1112 of human SENP6 (NP_056386.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur SENP6

Antigène: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Autre désignation: SENP6 (SENP6 Produits)

Synonymes: anticorps SSP1, anticorps SUSP1, anticorps 2810017C20Rik, anticorps E130319N12Rik, anticorps Susp1, anticorps mKIAA0797, anticorps fc83h02, anticorps im:7148342, anticorps wu:fc83h02, anticorps zgc:171230, anticorps SUMO1/sentrin specific peptidase 6, anticorps SUMO/sentrin specific peptidase 6, anticorps SUMO1/sentrin specific peptidase 6a, anticorps SENP6, anticorps Senp6, anticorps senp6a

Sujet: Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1, MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA, MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009],SSP1,SUSP1,SENP6,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Ubiquitin,SENP6

ID gène: 26054

UniProt: Q9GZR1