TNKS anticorps (AA 1050-1150)

N° du produit ABIN7270725

Détail du produit anti-TNKS anticorps

Antigène: TNKS (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS))

Épitope: AA 1050-1150

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNKS est non-conjugé

Application: Western Blotting (WB)

Fonction: TNKS Rabbit pAb

Séquence: EQITLDVLAD MGHEELKEIG INAYGHRHKL IKGVERLLGG QQGTNPYLTF HCVNQGTILL DLAPEDKEYQ SVEEEMQSTI REHRDGGNAG GIFNRYNVIR I

Réactivité croisée: Humain

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: A synthetic peptide corresponding to a sequence within amino acids 1050-1150 of human TNKS (NP_003738.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur TNKS

Antigène: TNKS (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS))

Autre désignation: TNKS (TNKS Produits)

Synonymes: anticorps wu:fe02c12, anticorps ARTD5, anticorps PARP-5a, anticorps PARP5A, anticorps PARPL, anticorps TIN1, anticorps TINF1, anticorps TNKS1, anticorps pART5, anticorps 4930554K12Rik, anticorps AI662855, anticorps C86528, anticorps D130072O21Rik, anticorps TANK1, anticorps mTNKS1, anticorps tankyrase-1, anticorps tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase b, anticorps tankyrase, anticorps tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase, anticorps tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 S homeolog, anticorps tnksb, anticorps TNKS, anticorps Tnks, anticorps tnks2.S

Sujet: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity.,TNKS,ARTD5,PARP-5a,PARP5A,PARPL,TIN1,TINF1,TNKS1,pART5,tankyrase,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Wnt/β-Catenin Signaling Pathway,TNKS

Poids moléculaire: 67kDa/142kDa

ID gène: 8658

UniProt: O95271